HESI - RISK21 Roadmap

About RISK21

Mission

Harmonize the approach to how the world evaluates chemicals using a risk-based approach.

Principles of RISK21

• Problem-formulation based
• Risk-based at each step of the process
• Use of prior knowledge
• Fit for purpose
• Value of information
• “Enough precision to make the decision”
• Provide a framework that is flexible, transparent, visual

Impact

• Developed a risk assessment approach that embraces advance in scientific knowledge and methods
• Actively involved over 120 participants (government, industry, academia, NGOs) through 6 years of work
• Published 8 manuscripts in Critical Reviews in Toxicology
• Reached over 500 participants in 5 countries on three continents via 7 hands-on case-study workshops
• Revised current thinking about how to approach the science and art of risk assessment

Next Steps

• Continued outreach and communication
• Additional illustration and application via case studies
• Ongoing dialog on advances and needs

Version 2.0 of the RISK21 Webtool is Now Available!

21st Century Framework

The webtool supports a problem formulation-based, exposure-driven, tiered acquisition approach that leads to an informed decision.

Transparent and Consistent

The webtool approach allows users to optimize the use of resources and information available for chemical risk assessment.

Create Custom Plots

Users can interact with the RISK21 webtool application to visualize their own risk data, creating a custom plot which will be displayed on the screen.

RISK21 Roadmap and Matrix

The RISK21 webtool application allows users to input estimated exposure and toxicity data for each chemical, and will plot the intersection area, overlaying a risk matrix represented as a heat map.